Toke Bek Selected Research

Hypercapnia

1/2020	Dilatation of Retinal Arterioles Induced by Topical Dorzolamide for One Week Is Impaired in Patients with Type 1 Diabetes and Mild Retinopathy.
1/2009	The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition.

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Toke Bek Research Topics

Disease

46	Diabetic Retinopathy (Retinopathy, Diabetic) 11/2023 - 01/2002
25	Macular Degeneration (Age-Related Maculopathy) 01/2020 - 12/2002
17	Hypoxia (Hypoxemia) 01/2023 - 09/2013
14	Vascular Diseases (Vascular Disease) 10/2023 - 05/2008
11	Retinal Diseases 08/2023 - 11/2004
9	Type 2 Diabetes Mellitus (MODY) 11/2023 - 10/2006
7	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2024 - 03/2003
7	Glaucoma 08/2022 - 10/2007
6	Choroidal Neovascularization 06/2024 - 11/2009
6	Retinal Vein Occlusion 03/2023 - 06/2009
6	Ischemia 10/2019 - 01/2009
6	Macular Edema 01/2019 - 12/2002
4	Blindness (Hysterical Blindness) 11/2023 - 01/2002
4	Vision Disorders (Hemeralopia) 11/2021 - 08/2012
4	Diabetes Mellitus 10/2017 - 06/2003
3	Myopia 02/2024 - 02/2023
3	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2017
2	Autosomal Dominant Optic Atrophy (Dominant Optic Atrophy) 01/2023 - 01/2022
2	Hypertension (High Blood Pressure) 08/2022 - 10/2011
2	Hypercapnia 01/2020 - 01/2009
2	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2019 - 01/2017
2	Brain Diseases (Brain Disorder) 01/2019 - 01/2017
2	Atrophy 01/2019 - 01/2017
2	Hyperglycemia 01/2019 - 12/2013
2	Auditory neuropathy 02/2018 - 01/2018
2	CAPOS syndrome 02/2018 - 01/2018
2	Ganglion Cysts (Ganglion) 01/2018 - 06/2012
2	Acidosis 01/2009 - 05/2006
1	Hypothyroidism 05/2024
1	Hyperthyroidism 05/2024
1	Weight Loss (Weight Reduction) 11/2023
1	Diabetic Neuropathies (Diabetic Neuropathy) 10/2023
1	Retinal Artery Occlusion 03/2023
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2023
1	Stroke (Strokes) 08/2022
1	Cataract (Cataracts) 08/2022
1	Myocardial Ischemia (Ischemic Heart Diseases) 08/2022
1	Peripheral Arterial Disease 08/2022
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022
1	Strabismus (Squint) 01/2022
1	Disease Progression 01/2021
1	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/2020
1	Retinal Telangiectasis 11/2019

Drug/Important Bio-Agent (IBA)

78	Retinaldehyde (Retinal)IBA 10/2023 - 01/2002
18	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2024 - 09/2010
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 07/2015
6	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2017 - 07/2015
5	Proteins (Proteins, Gene)FDA Link 06/2019 - 02/2007
4	CholesterolIBA 03/2023 - 12/2002
4	ProstaglandinsIBA 01/2023 - 09/2013
4	MicroRNAs (MicroRNA)IBA 06/2019 - 01/2015
4	Diclofenac (SR 38)FDA LinkGeneric 10/2017 - 12/2012
3	Antihypertensive Agents (Antihypertensives)IBA 05/2024 - 12/2011
3	Atropine FDA LinkGeneric 02/2024 - 02/2023
3	Ibuprofen (Motrin)FDA LinkGeneric 01/2023 - 08/2015
3	Carbonic Anhydrase InhibitorsIBA 01/2020 - 01/2009
3	Oxygen (Dioxygen)IBA 01/2019 - 02/2014
3	Biomarkers (Surrogate Marker)IBA 01/2019 - 01/2017
3	omega-N-Methylarginine (NG Monomethyl L Arginine)IBA 10/2017 - 07/2015
3	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 08/2015
2	Ophthalmic Solutions (Eye Drops)IBA 02/2024 - 10/2023
2	LipidsIBA 10/2023 - 10/2013
2	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 01/2019
2	Insulin (Novolin)FDA Link 09/2023 - 03/2023
2	Adenosine Triphosphate (ATP)IBA 01/2023 - 10/2013
2	Adenosine (Adenocard)FDA LinkGeneric 01/2023 - 05/2019
2	Adenosine Triphosphatases (ATPase)IBA 02/2018 - 01/2018
2	NG-Nitroarginine Methyl Ester (L-NAME)IBA 01/2017 - 08/2015
2	Retinal Pigments (Pigments, Visual)IBA 01/2017 - 01/2016
2	Hemoglobins (Hemoglobin)IBA 10/2016 - 10/2014
2	Synthetic Prostaglandins (Prostaglandin Analogues)IBA 09/2013 - 02/2013
2	Small Interfering RNA (siRNA)IBA 11/2012 - 09/2010
2	Lisinopril (Prinivil)FDA LinkGeneric 12/2011 - 06/2003
1	Thyroid HormonesIBA 05/2024
1	NeuropeptidesIBA 08/2023
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 02/2023
1	alpha,beta-methyleneadenosine 5'-diphosphateIBA 01/2023
1	semaglutideIBA 01/2023
1	empagliflozinIBA 01/2023
1	N- (4- cyanophenyl)- 2- (4- (2,3,6,7- tetrahydro- 2,6- dioxo- 1,3- dipropyl- 1H- purin- 8- yl)- phenoxy)acetamideIBA 01/2023
1	2,3- diethyl- 4,5- dipropyl- 6- phenylpyridine- 3- thiocarboxylate- 5- carboxylateIBA 01/2023
1	ectoATPaseIBA 01/2023
1	sortilinIBA 01/2023
1	pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acidIBA 01/2023
1	2-acetylhydrazide 8-chloro- Dibenz(b,f)(1,4)oxazepine- 10(11H)- carboxylic acidIBA 01/2023
1	Purinergic P1 Receptor AntagonistsIBA 01/2023
1	TabletsIBA 01/2023
1	1- (4- fluorobenzoyl)- 3- (((6- methoxy- 2- naphthyl)oxy)methyl)azetidine- 3- carboxylic acidIBA 01/2023
1	PurinesIBA 01/2023
1	ORALIT (ORS)IBA 08/2022
1	dorzolamide (Trusopt)FDA LinkGeneric 01/2020

Therapy/Procedure

9	Light Coagulation 03/2022 - 08/2004
6	Lasers (Laser) 01/2021 - 02/2006
5	Therapeutics 08/2023 - 01/2002
3	Injections 11/2018 - 11/2012
3	Aftercare (After-Treatment) 11/2018 - 01/2017
2	Vitrectomy 03/2022 - 02/2006
1	RNAi Therapeutics 06/2024
1	Bariatric Surgery 11/2023
1	Decompression 01/2022